This sounds like a formula, and it is a formula. But "Midnight Run" is not a formula movie, because the writing and acting make these two characters into specific, quirky individuals whose relationship becomes more interesting even as the chase grows more predictable.
Whoever cast De Niro and Grodin must have had a sixth sense for the chemistry they would have; they work together so smoothly, and with such an evident sense of fun, that even their silences are intriguing.
De Niro does not usually appear in movie comedies, and when he does, as in "Brazil," it's usually in some sort of bizarre disguise.
Here he proves to have comic timing of the best sort - the kind that allows dramatic scenes to develop amusing undertones while still working seriously on the surface. It's one thing to go openly for a laugh. It's harder to do what he does and allow the nature of the character to get the laughs, while the character himself never seems to be trying to be funny.
De Niro is often said to be the best movie actor of his generation. Grodin has been in the movies just about as long, has appeared in more different titles, and is of more or less the same generation, but has never received the recognition he deserves - maybe because he often plays a quiet, self-effacing everyman. In "Midnight Run," where he is literally handcuffed to De Niro at times, he is every bit the master's equal, and in the crucial final scene it is Grodin who finds the emotional truth that defines their relationship.
The movie develops that relationship during and between a series of virtuoso action sequences, after De Niro finds Grodin in New York and sets out to return him to Los Angeles. Grodin is afraid of flying, so the two men set out on a long, cross-country odyssey that involves train trips, a shootout at the Chicago bus ter minal, hitchhiking, riding the rails in box cars, and being attacked by helicopters.
Their pursuers come in waves. The FBI is led by agent Alonzo Mosely (Yaphet Kotto), who is enraged because De Niro has stolen his FBI identification and is posing as a federal agent. The mob's team is deployed by Jimmy Serrano (Dennis Farina), who grows increasingly enraged as his hit squads miss their targets.
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